Sr Associate Scientist, Chem & Mol Therapeutics

About This Role  The BioDesign Protein Biohemistry group at Biogen is seeking a creative and self-motivated scientist to contribute to our mission to design and develop medicines to transform patients’ lives. The successful candidate will play a key role in designing, generating, and characterizing antibody-oligonucleotide conjugates intended to improve the delivery of therapeutic oligonucleotides (ASOs or siRNAs) to target tissues.  This role requires a strong background in protein chemistry with extensive experience in bioconjugation and a deep understanding of linker design and optimization to improve the stability, efficiency, and efficacy of antibody-oligonucleotide conjugates. What You’ll Do Optimize and implement protein purification schemes for engineered antibodies using computer-interfaced chromatography systems (e.g., AKTA or similar) Characterize proteins using standard methods such as SDS-PAGE, analytical size-exclusion chromatography, and dynamic light scattering Work with a cross-functional team to design and test novel linker chemistries to enhance conjugate stability and performance Develop and optimize novel antibody-oligonucleotide conjugation and purification methods Generate, purify, and analyze antibody-drug conjugates for use in animal models. Actively contribute to project strategy and experimental design, and regularly present findings at team meetings Troubleshoot technical challenges and drive continuous improvements in conjugation and purification workflows Who You Are The ideal candidate has a strong background in bioconjugation methods, a passion for science, and a genuine enthusiasm for collaborating within a cross-functional team.