Description:Scientist I The successful candidate will be responsible for non-regulated quantitative LC-MS/MS bioanalysis of small molecules from in vivo samples including extraction data analysis and interpretation. First Shift Mon-Fri 8am - 5pm possibility of earlier than 8am depending on job tasks Level and compensation will be commensurate with experience. Key Responsibilities Include:
Use liquid handling robotics.
Perform quantitative LC-MS/MS Liquid Chromatography Mass Spectrometry analysis of small molecules from various bio-matrices in vivo and in vitro to support PK/PD ADME efficacy and exploratory toxicology studies.
Basic Operation and troubleshooting of AB Sciex LC-MS/MS systems.
Maintain excellent documentation of all work including LIMS test methods and protocols.
Work closely with multiple teams across Discovery and DMPK-BA to support bioanalysis.
Qualifications:
B.S. in analytical chemistry or related field years of relevant academic/pharmaceutical industry experience.
Knowledge of protein precipitation liquid/liquid extraction and solid phase extraction.
Ability to operate and troubleshoot HPLCs Leap/CTC PAL autosamplers and triple quad mass spectrometers.
Experience with quantitative bioanalysis of small molecules.
Knowledge of chromatographic and analytical methodologies.
The ideal candidate is detail oriented and committed to generating high-quality results within tight deadlines and across different projects.
Proven ability to work independently or under minimal supervision in a high-throughput environment to design and conduct experiments interpret document and communicate results as well as in a team environment to collaborate successfully across other groups within RD.
Strong communication interpersonal and presentation skills.
Experience operating and troubleshooting current LC-MS/MS platforms Agilent HPLCs Leap/CTC PAL and ADDA autosamplers Sciex API-5500/6500 triple quad Mass Spectrometers and software e.g. Discovery Quant Analyst Electronic notebook is highly preferred.
Key Leadership Competencies:
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
Learns fast grasps the essence and can change course quickly where indicated.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment open to suggestions and experimentation for improvement.
Embraces the ideas of others nurtures innovation and manages innovation to reality.
Skills & Qualifications:
B.S. in analytical chemistry or related field years of relevant academic/pharmaceutical industry experience.
Knowledge of protein precipitation liquid/liquid extraction and solid phase extraction.
Ability to operate and troubleshoot HPLCs Leap/CTC PAL autosamplers and triple quad mass spectrometers.
Experience with quantitative bioanalysis of small molecules.
Experience Level:Intermediate LevelAbout Actalent Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.Diversity, Equity & Inclusion At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I are embedded into our culture through:
Hiring diverse talent
Maintaining an inclusive environment through persistent self-reflection
Building a culture of care, engagement, and recognition with clear outcomes
Ensuring growth opportunities for our people
The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email [email protected] (%[email protected]) for other accommodation options.