Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs: ARV-766 and bavdegalutamide for the treatment of men with metastatic castration-resistant prostate cancer; and vepdegestrant (ARV-471) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. Arvinas, as part of its overall business strategy, selectively assesses opportunities for potential collaboration, license, marketing and royalty arrangements, and similar transactions, to advance and accelerate the development and enhance the commercial potential of its product candidates.#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say .For more information, please visit www.arvinas.com .Position SummaryWe are looking for a summer intern to strengthen our VHH nanobody screening process. This committed internship position will be responsible for developing small to medium scale high throughput VHH nanobody protein expression in E. coli cells and VHH protein purification.This position reports to the leader of the selection team and will be located at our headquarters in New Haven, CT.Principal ResponsibilitiesKey responsibilities of this role include, but are not limited to:
Test and develop small to medium scale protein expression and purification protocols by column and/or plate-based purification methods.
Carry out expression and purification experiments.
Assay to rank order VHH proteins based on EC50.
Analyze, interpret, and report experimental results at internal meetings.
Maintain detailed records of experiments in electronic lab notebooks in line with company policy.
Contribute to conceptions, presentations, publications, and patents.
Maintain a knowledge of literature related to areas of research.
If there is time left in the internship, the intern may clone peptide or nanobody libraries and/or carry out selection (bio-panning).
Qualifications
Required skills:
Experience in protein expression in E. coli culture
Experience with protein characterization and protein purification such as SDS-PAGE, IMAC and/or ion exchange purification
Experience in standard molecular biology applications (PCR, cloning).
Maintaining safe working environment for self and others
Maintaining orderly and timely record of experiments and results in accordance with company policy and legal requirements
Preferred skills:
Experience with ELISA and/or other protein interaction assays
Sanger and/or NGS sequencing
Good aseptic technique
A successful candidate will have an enabling attitude, be a problem solver, and have a desire to work in a collaborative manner with peers and pan-disciplinary colleagues in a project setting.
Education
Pursuing M.S./PhD in protein engineering, biochemistry, molecular biology, biomedical engineering, or a related field
#LI-RemoteArvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.comArvinas is an Equal Opportunity Employer