Genomic Medicine Purification Process Development Co-Op, Waltham, MAPosition Overview/Department Description
The Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant Adeno-associated viral vectors (AAV), non-viral and cell therapy products. This 6-month position centers on drug substance process development for gene therapy but will interface with a broader team of vector and cell line engineering, upstream process development, analytics, and clinical manufacturing support.
A successful candidate in this role will be engaged in actively learning new techniques, independently performing experiments, analyzing and presenting results, and collaborating with different functions to understand the cross-functional nature of decision-making.
Experience in protein characterization, high-throughput, engineering and data analysis, analytical techniques, and/or viral vector purification is preferred. Project topic will be commensurate with level of previous experience.
Key Responsibilities
Design, and execute viral vector purification experiments.
Perform analytical characterization of samples and analyze results.
Work with cross-functional team for feedback and present findings.
Contribute to technical reports and/or external publications if appropriate to project topic and level of experience.
Basic Qualifications
Currently pursuing PhD, MS, or BS study in chemistry, chemical engineering, or biological engineering with relevant study experience.
Understanding of drug substance purification process concepts.
Theoretical and practical knowledge of mass transfer and fluid dynamics.
Knowledge and understanding of technologies and operations such as:
Chromatography, tangential flow filtration, normal flow filtration, and/or viral clearance and inactivation
Advanced analytical tools to characterize particles and viral vectors
Work under minimal supervision and function within a collaborative, team-oriented environment.
Ability to work in Biosafety Level 2, follow safe lab procedures, and maintain good laboratory practices (GLPs) including detail-oriented laboratory notebook documentation.
Preferred Qualifications
Experience with viral vector purification and characterization.
Experience with SEC-HPLC, DLS, ddPCR/qPCR, Western blot, ELISA, spectroscopic and bioassay techniques.
Experience with AKTA chromatography and filtration instruments.
Experience with protein characterization such as NanoSight 3000, Caliper LabChip GXII, Multi-Angle LS (MALS), or similar instruments.
Basic understanding of the principles of Quality by Design and ability to apply DOE to downstream development.
Excellent communication skills and ability to build cross-functional relationships.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.#GD-SA#LI-SAPursue progress , discover extraordinaryBetter is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) !