Scientist, In Vivo Discovery

We are seeking a scientific contributor to lead and execute in vivo studies using novel LNP formulations designed to cross the BBB and target cells within the brain. This role will spearhead our CNS program and would be responsible for designing and executing in vivo studies using rodent models as well as downstream bioanalytic methods. The candidate would have the opportunity to work in a collaboration-oriented role in which they would coordinate with other teams, plan and run animal studies with a cross-functional group of scientists, and support the growth and career development of junior scientists. The ideal candidate is a life sciences major with strong in-vivo and ex-vivo analytic techniques who is excited by the idea of being a core participant in building an early startup and guiding the scientific vision of the company. They would be engaged in science and driven by our mission to create therapies that help people in ways that are currently impossible.Key ResponsibilitiesDesign, plan and execute in vivo experiments to support LNP based targeted delivery across the blood brain barrier through systemic administrationDevelop bioanalytical assays (cell-based, flow cytometry, ELISA, biomedical imaging) to assess the delivery efficiency of RNA cargo in rodent tissue to facilitate development of neuroscience focused therapeutics pipelineConduct studies in small animals models for brain characterization, biodistribution (qualitative/quantitative), disease model development, efficacy and toxicity assessmentContribute to patent applications related to the neuroscience programPerform CRO outreach including experimental planning, work coordination and data interpretation for neuroscience programSupport technology transfer to Industry PartnersFoster collaborative relationships across the team and company and engage in a positive and exciting work environmentContribute to hiring, training, and collaborating with scientists (as needed) to support assessment of efficacy in relevant in vivo modelsPlan and coordinate animal studies with formulations team membersAuthor technical documents, including SOPs for analytical methods, maintain diligent records and demonstrate proficiency in scientific communicationSupport high-quality documentations to support regulatory filings