Vacancy caducado!
- Specializing in pharmacokinetics and pharmacology to join protein therapeutics/biologics discovery efforts
- Work with a world-class, multidisciplinary team of drug discovery scientists to lead the in vitro and in vivo ADME, PK, PD and toxicokinetic efforts to support biologics drug discovery and development.
- Design, manage, and execute in vitro and in vivo programs both in-house and at contract research organizations.
- Responsible for analyzing, interpreting, and modeling DMPK and PK/PD data.
- Design, conduct, and manage in vitro, and in vivo experiments to evaluate the ADME and PK profiles of developmental biologics candidates both in-house and at contract research organizations
- Develop and execute assays for measuring drug concentration, target engagement, and pharmacodynamic effects in vitro and in vivo
- Champion innovation and new initiatives in discovery programs by proactively reviewing literature and other advancements in disease area biology
- Interpret and present research data and findings in internal and external scientific meetings and conferences
- Contribute effectively to patents, reports, and publications of scientific findings
- PhD in Pharmacy, Pharmacometrics, Chemistry, Biochemistry, or related field with 1-10 years (or MS with 5+ years) of BioPharma industrial experience in DMPK and/or Clinical Pharmacology
- Demonstrated knowledge of ADME, PK/PD
- Experience with biomolecule, gene therapy, or mRNA therapeutics is a plus
- Experience in bioanalytical techniques including assays for immunogenicity, in vitro and in vivo toxicology, and histopathology preferred
- Experience in assay development for target engagement and biomarker discovery preferred Hands-on experience with LC-MS to analyze biological drug candidates preferred
- Experience in contributing DMPK and pharmacology parts of regulatory submission preferred
- Ability to collaborate with an interdisciplinary team with excellent written and oral communication skills
- Ability to multi-task to meet research and development goals
- Drive to solve problems and ability to work independently
Vacancy caducado!