Senior Scientist Vector and Cell-line development Summary: Catalent Cell and Gene Therapy is looking to recruit a Senior Scientist Vector and Cell-line development to join our growing team in Baltimore, MD.Catalent, Inc. is a leading global contract development and manufacturing organization (CDMO) whose mission is to develop, manufacture, and supply products that help people live better and healthier lives. Catalent is dedicated to delivering unparalleled service to pharma, biotech, and consumer health customers, supporting product development, launch, and full life-cycle supply. With time-tested experience in development sciences, delivery technologies, and multi-modality manufacturing, Catalent supports the acceleration of development programs and the launch of more than a hundred new products every year. Powered by thousands of scientists and technicians and the latest technology platforms at more than 40 global sites, Catalent supplies billions of doses of life-enhancing and life-saving treatments for patients annually.The Viral Vector R&D, Product Development Team supports development of AAV, LVV viral therapies, vector development, cell-line development, Innovation areas including mRNA, exosomes, enzymes, viral proteins. In addition, the Innovation team participates in due diligence evaluation of partners, vendors, and potential acquisition targets. Within Biomodalities, the C> business unit continues to develop technology in-house and evaluates potential external offerings. The team also supports Master Cell Bank production, Plasmid Master Banks, and collaborates with Manufacturing Science and Technology (MS&T) to support tech transfer and provide investigation support to GMP. In addition, novel technologies are progressed through a Catalent corporate initiative, for creating integrated Platform offerings to our customers. People joining our team will have the opportunity for career development as our business continues to grow and expand. The successful candidate will work with a team of scientists from Process Development to enable the delivery of life-changing gene therapies to patients. The Senior Scientist, Cell-line development will be recognized as a technical expert and a scientific lead. He/she will be responsible for new technology evaluation, development, and implementation for improved workflows and systems. The candidate will be forecasting and planning resource requirements for projects assigned. Finally, the successful candidate will undertake mentoring of team members to guide them in developing novel cell-lines and processes.Catalent is committed to a Patient First culture through excellence in quality and compliance, and to the safety of every patient, consumer and Catalent employee .This is a full-time on-site position, Monday – Friday 8:00am-5:00pm The Role:
Generate stable packaging and produce cell lines and clones for clinical and commercial programs for AAV, and lentiviral vectors
Design and evaluate novel plasmid vectors for optimal AAV, and/or lentiviral yields along with improved packaging.
Execute the cell line development programs to develop robust, highly productive cell lines which encompass plasmid construction, transfection, cloning, high-throughput plate-based screening, and execution of cell line screening experiments using a high-throughput ambr bioreactor system.
Propose and execute technology improvements to the host cell line, equipment, and methods, furthering their own skill sets while advancing the capabilities of the group.
Evaluate novel cell transfection and cell activation/expansion strategies.
Novel methods development to support new modalities for in-process assays. Perform various immunological and cell-based assays to support client research.
Must be a strong team player and can collaborate effectively on complex projects.
Demonstrates capability to mentor junior colleagues in a team environment.
Troubleshoot scientific and technical challenges and contribute to their resolution.
Ensures effective, and timely documentation in laboratory notebooks and internal Technical Reports.
Other duties as assigned.
The Candidate:
PhD degree in a biological or engineering discipline (biology, biochemistry, molecular biology, or equivalent) with 7+ years of experience OR
MS degree in a biological or engineering discipline (biology, biochemistry, molecular biology, or equivalent) with 9+ years of experience
Experience with a wider array of cell types to include HEK293, NK cells, T, NK, Treg, Mac, TCR, TIL, and others is a plus.
Sequencing approaches including PacBio, ONT NGS experience is desired
The successful candidate will possess strong oral and written communication skills.
Experience with preparation of regulatory documents is a plus
Excellent problem solving as well as and written/verbal communication skills
Strong interpersonal skills, and ability to work effectively on teams
Routinely suggests new, innovative solutions to routine, and complex problems
Experience with various cell-lines for recombinant protein and gene therapy vector expression, process development, and/or bioprocess manufacturing.
Ability to execute detailed experimental plans, record procedures, analyze data, and present results.
The anticipated salary range for this position in Maryland is $118,720 - $163,240 plus an annual bonus, when eligible. The final salary offered to a successful candidate may vary, and will be dependent on several factors that may include but are not limited to: the type and length of experience within the job, type and length of experience within the industry, skillset, education, business needs, etc. Catalent is a multi-state employer, and this salary range may not reflect positions that work in other states.Why You Should Join Catalent:
Defined career path and annual performance review and feedback process
Diverse, inclusive culture
Potential for career growth on an expanding team within an organization dedicated to preserving and bettering lives
152 hours of paid time off annually + 8 paid holidays
Competitive salary with yearly bonus potential
Community engagement and green initiatives
Generous 401K match and Paid Time Off accrual
Medical, dental and vision benefits effective day one of employment
Tuition Reimbursement
Catalent offers rewarding opportunities to further your career! Join the global drug development and delivery leader and help us bring over 7,000 life-saving and life-enhancing products to patients around the world. Catalent is an exciting and growing international company where employees work directly with pharma, biopharma and consumer health companies of all sizes to advance new medicines from early development to clinical trials and to the market. Catalent produces more than 70 billion doses per year, and each one will be used by someone who is counting on us. Join us in making a difference. personal initiative. dynamic pace. meaningful work.Visit Catalent Careers (https://careers.catalent.com/us/en) to explore career opportunities.Catalent is an Equal Opportunity Employer, including disability and veterans.If you require reasonable accommodation for any part of the application or hiring process due to a disability, you may submit your request by sending an email, and confirming your request for an accommodation and include the job number, title and location to [email protected] . This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Catalent employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.Notice to Agency and Search Firm Representatives: Catalent Pharma Solutions (Catalent) is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Catalent employee by a third party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Catalent. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral. Thank you.Important Security Notice to U.S. Job Seekers:Catalent NEVER asks candidates to provide any type of payment, bank details, photocopies of identification, social security number or other highly sensitive personal information during the offer process, and we NEVER do so via email or social media. If you receive any such request, DO NOT respond— it is a fraudulent request. Please forward such requests to [email protected] for us to investigate with local authorities.California Job Seekers can find our California Job Applicant Notice HERE (https://cdn.catalent.com/files/legal/CCPA-Privacy-Notice-at-Collection-for-California-Employees-and-Applicants-English.pdf) .