Associate Director, Clinical Operations - Oncology (Compound Lead) (Office Based 3X/wk)

The Associate Director, Clinical Operations will provide strategic leadership and oversight for the planning, execution, and delivery of global clinical trials from study start-up through close-out. This role is accountable for ensuring that clinical programs are executed in alignment with corporate goals, regulatory requirements (ICH-GCP and local regulations), and industry best practices. The Associate Director will lead cross-functional teams, manage external partners (e.g., CROs, vendors), and drive operational excellence across multiple studies or programs. This position plays a critical role in risk management, resource planning, and ensuring that timelines, budgets, and quality standards are consistently met. This role is based in our South San Francisco, CA office. Lead the operational strategy and execution of one or more global clinical trials, ensuring alignment with corporate objectives and regulatory standards.Own the end-to-end delivery of assigned clinical trials, including country and site selection, site start-up, contracting, patient recruitment, and retention strategies, ensuring timelines, budgets, and quality metrics are met.Drive cross-functional collaboration to develop and finalize critical clinical trial documents and systems, including protocols, informed consent forms (ICFs), budget templates, EDC, IxRS, central/specialty labs, ECG, imaging, PRO specifications, drug supply logistics, biomarker/sample management plans, TMF, and CSRs.Develop and implement comprehensive study plans encompassing vendor oversight, risk management, quality assurance, safety monitoring, communication strategies, trial monitoring, and TMF management.Ensure timely creation, maintenance, and quality control (QC) of the Trial Master File (TMF) in compliance with regulatory and internal standards.Provide oversight and support for clinical systems including EDC, IxRS, and CTMS, ensuring data accuracy and operational efficiency.Monitor and manage study budgets, timelines, and milestones; proactively identify risks and implement mitigation strategies.Lead financial oversight of assigned studies, including vendor budget management, variance analysis, and resolution planning.Drive global vendor selection and management, including participation in the Request for Proposal (RFP) process and contract negotiations.Oversee outsourced activities to ensure CRO and vendor performance aligns with contractual obligations and quality expectations.Lead the planning and execution of Investigator Meetings in collaboration with cross-functional teams.Maintain up-to-date knowledge of relevant therapeutic areas and evolving clinical research practices to inform operational strategies.Ensure full compliance with ICH-GCP, regulatory requirements, and company SOPs across all assigned studies.Work across several time zones