Vacancy caducado!
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAt Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Quantitative Systems Pharmacology Modeler - Scientist II in our Cambridge, MA location.Objective / Purpose:As a Quantitative Systems Pharmacology Modeler - Scientist II in DMPK & Modeling, you will be empowered to interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development.Accountabilities:
Support decision making in the preclinical development of novel therapeutic agents to treat various diseases involving aberrant activation of the immune system, including irritable bowel disease (IBD), ulcerative colitis, liver fibrosis, dermatitis, and others.
Work on cross-functional teams with preclinical biology/pharmacology, clinical pharmacology, nonclinical safety assessment, and translational medicine to develop quantitative model-based understanding of both the target biological pathways and novel therapeutic agents.
May involve early feasibility assessment for novel targets, reverse translation from clinical comparators for validates ones, and/or building pharmacokinetic/pharmacodynamic (PK/PD), physiologically based pharmacokinetic (PBPK), and quantitative systems pharmacology (QSP) models for distribution, pharmacology, and efficacy of novel agents.
Implement a modeling & simulation strategy to assist and accelerate decisions around preclinical study design and interpretation, as well as prediction of first-in-human dose and safety margins for clinical trials.
Education & Competencies
Ph.D/Pharm.D in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
Strong competency in building mathematical models is required (in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R)
At least 2 years (5 years with MS) of industry experience in mathematical modeling of biological systems.
Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions related to projects.
Ability to communicate complex modeling results clearly and concisely to cross-functional audience is critical.
Prefer candidates with background or interest in immunology or biology of GI diseases.
Job title is flexible based on experience.
This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policyTakeda Compensation and Benefits SummaryWe understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.For Location:Boston, MAU.S. Base Salary Range:$133,000.00 - $209,000.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time