Bioinformatics Scientist

About the Role:At Guardant Health, we are committed to positively and significantly impacting patient health through technology breakthroughs that address long-standing unmet needs in oncology. The Bioinformatics, BioPharma team at Guardant Health is focused on partnerships with leading biotech and pharma companies who are at the forefront of cancer therapeutics and diagnostics. In this role, you will play a key leadership role in bioinformatics and data analysis, supporting the development of emerging technologies. You will collaborate with BioPharma and clinical partners, customize analyses to meet the unique needs of each organization, and address some of the most compelling biological and technical challenges in the field.You will contribute to novel project initiatives in-house, including the development of novel bioinformatics and analytical methods. As a member of the Bioinformatics and BioPharma team, you will have the opportunity to drive innovation and implement new ideas, continuously enhancing our emerging technology products and analytics to align with the evolving needs of the BioPharma landscape.You will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based transcript expression and methylation data integrated with epigenetic data sets. You will work together with our collaborators in industry, hospitals and academia on high-impact translational research and publish on your findings. You will have access to the unprecedented compendium of data collected at Guardant Health and you will be able to (and should be excited to!) leverage this data for tumor biology and technological insights.Essential Duties and Responsibilities:Work with large, complex data sets.Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data.Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies.Systematically leverages external innovation ideas and expertise to address technology gaps and advance the Guardant Health's business.Provide analytical support on individual samples and research activities.Deliver analytical support for clinical operations in compliance with CLIA and CAP regulatory standards.Analyze genomic data from clinical patients and external annotation sources to improve the accuracy and quality of reporting.Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency.Communicate research results through presentations and project reports as well as scientific publications.