Post Doctorate RA - Neuroproteomics

Organization and Job ID Job ID: 309792Directorate: Earth & Biological SciencesDivision: Biological SciencesGroup: BioStructure & FunctionJob Description A post-doctoral position is available in Integrative Omics group at PNNL for collaborative project involving Columbia University and Rush Alzheimer’s Disease Center.The successful applicant will be immersed into application of proteomics to the research of Alzheimer’s disease and associated pathologies affecting cognition. In broad terms, the project involves discovery and validation of novel drug target candidates. The discovery component will rely on both prior available genomics and shotgun proteomics focused on a number of post-translational modifications that will be acquired during the course of the project. Validation component employs automated large-scale (>1,000 samples) quantitative targeted proteomics (SRM) analysis of the protein of interest or their modifications. Finally, the specific role of proteins in cognitive decline will be inferred using advanced statistical modeling techniques.This post-doctoral position provides an opportunity to learn a variety of proteomics techniques, the latest developments in Alzheimer’s disease research and statistical analysis of omics and clinical data. The latest research along this direction can be learned from the following publications:https://www.ncbi.nlm.nih.gov/pubmed/31009033 https://www.ncbi.nlm.nih.gov/pubmed/30137212 https://www.ncbi.nlm.nih.gov/pubmed/29908079 https://www.ncbi.nlm.nih.gov/pubmed/29416036 Details about the proteomics group in general can be learned at the web site: https://omics.pnl.gov/ Minimum Qualifications Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university.Preferred Qualifications The successful candidate will have a Ph.D. in one of the disciplines: neurobiology, neurology, biochemistry or bioanalytical chemistry. Solid background in statistics and experience with statistical software is required. R or python programming skills is a plus.Equal Employment Opportunity Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at jobs.pnnl.gov.Directorate: Earth & Biological SciencesJob Category: Post-Graduates and Post-DocsGroup: BioStructure & FunctionOpening Date: 2019-09-18Closing Date: 2019-11-01